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KMID : 0861020190340010001
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Korea Journal of Herbology
2019 Volume.34 No. 1 p.1 ~ p.11
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Anti-inflammatory Effects of Canavaliae Semen(Canavalia gladiate) Extracts
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Yang Won-Kyung
Park Yang-Chun
Kim Han-Young
Kim Kun-Hoae
Roh Seong-Soo
Kim Seung-Hyung
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Abstract
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Objective : An allergy to peanuts is a major cause of fatal food-induced anaphylaxis, with food allergies becoming an increasingly important health research issue. Food allergy as clinical entity has been recongnized for many years, although there is yet no general concord as to the incidence of this symptom.
Methods : This study was undertaken to verify the effect of seeds of Canavalia gladiata (Jacq.) DC. extract (CGE) on the inhibition of allergic reactions using a cholera toxin and peanut extract-immunized food allergy mouse model. We determine whether the changes in rectal temperature were related to energy consumption owing to heat production in the body. Mast cell distribution and degranulation in the dermis and epidermis were observed with an optical microscope. Subsequently, Ara h1 levels in serum and interleukin (IL)-4, IL-10, and IFN-γlevels in cultured supernatants of splenocytes were measured.
Results : CGE treatment significantly attenuated the secretion of the Ara h1 antibody in serum and splenocytes. Ara h 1 was undetected in the cholera toxin and peanut extract-immunized food allergy mouse model. Improvement in ear tissue inflammation symptoms was the CGE experimental group. In the control group and peanut extract control group, the expression of mast cells was higher, whereas that in the CGE experimental group was significantly lower.
Conclusion : CGE causes suppression in a food allergy mouse model via the inhibition of Ara h1 secretion, and might be useful for developing functional health foods.
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KEYWORD
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anti-allergy, Canavaliae Semen, Canavalia gladiata, cholera toxin, food allergy, immunogenicity, Systemic Anaphylaxis
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